Predicting seizure liability of small molecules using an in vitro multi-electrode array based assay coupled with modeling of brain disposition.
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| Title: | Predicting seizure liability of small molecules using an in vitro multi-electrode array based assay coupled with modeling of brain disposition. |
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| Authors: | Belair DG; Quantitative and Translational ADME Sciences, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Kohnken R; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., McCloud RL; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA., Sandoval S; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA., Green J; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Buck WR; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Polakowski JS; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA. |
| Source: | Current research in toxicology [Curr Res Toxicol] 2025 Apr 26; Vol. 8, pp. 100236. Date of Electronic Publication: 2025 Apr 26 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101771915 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-027X (Electronic) Linking ISSN: 2666027X NLM ISO Abbreviation: Curr Res Toxicol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 2666-027X |
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| DOI: | 10.1016/j.crtox.2025.100236 |
