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Predicting seizure liability of small molecules using an in vitro multi-electrode array based assay coupled with modeling of brain disposition.

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Title: Predicting seizure liability of small molecules using an in vitro multi-electrode array based assay coupled with modeling of brain disposition.
Authors: Belair DG; Quantitative and Translational ADME Sciences, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Kohnken R; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., McCloud RL; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA., Sandoval S; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA., Green J; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Buck WR; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA., Polakowski JS; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.
Source: Current research in toxicology [Curr Res Toxicol] 2025 Apr 26; Vol. 8, pp. 100236. Date of Electronic Publication: 2025 Apr 26 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101771915 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-027X (Electronic) Linking ISSN: 2666027X NLM ISO Abbreviation: Curr Res Toxicol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Belair+DG%22">Belair DG</searchLink>; Quantitative and Translational ADME Sciences, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.<br /><searchLink fieldCode="AU" term="%22Kohnken+R%22">Kohnken R</searchLink>; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.<br /><searchLink fieldCode="AU" term="%22McCloud+RL%22">McCloud RL</searchLink>; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA.<br /><searchLink fieldCode="AU" term="%22Sandoval+S%22">Sandoval S</searchLink>; Small Molecule Therapeutics and Platform Technologies, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60065, USA.<br /><searchLink fieldCode="AU" term="%22Green+J%22">Green J</searchLink>; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.<br /><searchLink fieldCode="AU" term="%22Buck+WR%22">Buck WR</searchLink>; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.<br /><searchLink fieldCode="AU" term="%22Polakowski+JS%22">Polakowski JS</searchLink>; Preclinical Safety, AbbVie Inc., 1 N Waukegan Rd, North Chicago, IL 60064, USA.
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  Data: <searchLink fieldCode="JN" term="%22101771915%22">Current research in toxicology</searchLink> [Curr Res Toxicol] 2025 Apr 26; Vol. 8, pp. 100236. <i>Date of Electronic Publication: </i>2025 Apr 26 (<i>Print Publication: </i>2025).
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        Value: 10.1016/j.crtox.2025.100236
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