Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity.
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| Title: | Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity. |
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| Authors: | Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Yang K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Al Nebaihi H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Wuest M; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Woodfield J; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Farraj RA; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Bhat RK; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Mangra-Bala IA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Shafaati T; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Ferrari SR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Wagg CS; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Capozzi ME; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Overduin M; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Velazquez-Martinez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Glover JNM; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Wuest F; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Brocks DR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada. |
| Source: | IScience [iScience] 2025 Apr 03; Vol. 28 (5), pp. 112336. Date of Electronic Publication: 2025 Apr 03 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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