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Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.

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Title: Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Authors: Kalin JH; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Yin Y; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Tran MT; Janssen Pharmaceutica N.V., Beerse, Belgium., Piassek M; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Fung A; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Grosse S; Janssen Pharmaceutica N.V., Beerse, Belgium., Jacoby E; Janssen Pharmaceutica N.V., Beerse, Belgium., Bhaumik A; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Adhikary S; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Miller R; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Lemmens C; Janssen Pharmaceutica N.V., Beerse, Belgium., Lutter FH; Janssen Pharmaceutica N.V., Beerse, Belgium., Pieters S; Janssen Pharmaceutica N.V., Beerse, Belgium., Cooymans L; Janssen Pharmaceutica N.V., Beerse, Belgium., Rombouts G; Janssen Pharmaceutica N.V., Beerse, Belgium., Oehlrich D; Janssen Pharmaceutica N.V., Beerse, Belgium., Tomaso S; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Lozada K; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Garcia MO; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Anson B; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., De Bruyn S; Janssen Pharmaceutica N.V., Beerse, Belgium., Smith-Monroy C; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Neefs J-M; Janssen Pharmaceutica N.V., Beerse, Belgium., Conceição-Neto N; Janssen Pharmaceutica N.V., Beerse, Belgium., Stoops B; Janssen Pharmaceutica N.V., Beerse, Belgium., van Vlijmen H; Janssen Pharmaceutica N.V., Beerse, Belgium., Patrick A; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Yu X; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Wong V; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Krosky D; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Abeywickrema P; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA., Mason S; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Jin Z; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA., Jonckers THM; Janssen Pharmaceutica N.V., Beerse, Belgium., Sharma S; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.
Source: Journal of virology [J Virol] 2025 Jul 22; Vol. 99 (7), pp. e0017825. Date of Electronic Publication: 2025 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
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  Data: Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
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Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Smith-Monroy+C%22">Smith-Monroy C</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Neefs+J-M%22">Neefs J-M</searchLink>; Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Conceição-Neto+N%22">Conceição-Neto N</searchLink>; Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Stoops+B%22">Stoops B</searchLink>; Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22van+Vlijmen+H%22">van Vlijmen H</searchLink>; Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Patrick+A%22">Patrick A</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wong+V%22">Wong V</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Krosky+D%22">Krosky D</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Abeywickrema+P%22">Abeywickrema P</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Spring House, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mason+S%22">Mason S</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22Jin+Z%22">Jin Z</searchLink>; Janssen Research & Development, LLC, a Johnson & Johnson Company, Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22Jonckers+THM%22">Jonckers THM</searchLink>; Janssen Pharmaceutica N.V., Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%220113724%22">Journal of virology</searchLink> [J Virol] 2025 Jul 22; Vol. 99 (7), pp. e0017825. <i>Date of Electronic Publication: </i>2025 Jun 02.
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