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Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia.

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Title: Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia.
Authors: Romero JC; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Tonapi SS; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Parihar M; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Loranc E; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Miller HE; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Lawrence LA; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Bassani N; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Robledo DG; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Cao L; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Nie J; Barshop Institute for Longevity and Aging Studies, Health San Antonio, San Antonio, TX, USA.; Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Kanda K; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Stoja A; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Garcia N; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Gorthi A; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA., Stoveken BJ; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA., Fan TW; Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Cassel TA; Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Zha S; Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Lechleiter JD; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Center for Precision Medicine, UT Health San Antonio, San Antonio, TX, USA., Musi N; Barshop Institute for Longevity and Aging Studies, Health San Antonio, San Antonio, TX, USA.; Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA., Dong LQ; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA., Lane AN; Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Bishop AJR; Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA. alexander.bishop@nationwidechildrens.org.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA. alexander.bishop@nationwidechildrens.org.; Barshop Institute for Longevity and Aging Studies, Health San Antonio, San Antonio, TX, USA. alexander.bishop@nationwidechildrens.org.; Mays Cancer Center, UT Health San Antonio, San Antonio, TX, USA. alexander.bishop@nationwidechildrens.org.; Nationwide Children's Hospital, Center for Childhood Cancer, Columbus, OH, USA. alexander.bishop@nationwidechildrens.org.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. alexander.bishop@nationwidechildrens.org.
Source: Nature communications [Nat Commun] 2025 Jun 02; Vol. 16 (1), pp. 5109. Date of Electronic Publication: 2025 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60304-4