Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.

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Title: Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.
Authors: Li F; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Department of Structural Biology, Amgen Research, South San Francisco, CA, USA. fli05@amgen.com., Eriksen J; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.; Nine Square Therapeutics, South San Francisco, CA, USA., Oses-Prieto JA; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Gomez YK; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Xu H; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Hareendranath S; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Das P; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Finer-Moore J; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Nguyen P; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Bowen A; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Nelson A; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Burlingame A; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Grabe M; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Stroud RM; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu.; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu., Edwards RH; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. robert.edwards@ucsf.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Aug; Vol. 32 (8), pp. 1479-1487. Date of Electronic Publication: 2025 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-9985
DOI:10.1038/s41594-025-01568-8