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Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.

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Title: Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2.
Authors: Li F; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Department of Structural Biology, Amgen Research, South San Francisco, CA, USA. fli05@amgen.com., Eriksen J; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.; Nine Square Therapeutics, South San Francisco, CA, USA., Oses-Prieto JA; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Gomez YK; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Xu H; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Hareendranath S; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Das P; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Finer-Moore J; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Nguyen P; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Bowen A; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Nelson A; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA., Burlingame A; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Grabe M; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA., Stroud RM; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu.; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu., Edwards RH; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. robert.edwards@ucsf.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Aug; Vol. 32 (8), pp. 1479-1487. Date of Electronic Publication: 2025 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. fli05@amgen.com.; Department of Structural Biology, Amgen Research, South San Francisco, CA, USA. fli05@amgen.com.<br /><searchLink fieldCode="AU" term="%22Eriksen+J%22">Eriksen J</searchLink>; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.; Nine Square Therapeutics, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Oses-Prieto+JA%22">Oses-Prieto JA</searchLink>; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gomez+YK%22">Gomez YK</searchLink>; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hareendranath+S%22">Hareendranath S</searchLink>; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Das+P%22">Das P</searchLink>; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Finer-Moore+J%22">Finer-Moore J</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+P%22">Nguyen P</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bowen+A%22">Bowen A</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+A%22">Nelson A</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Burlingame+A%22">Burlingame A</searchLink>; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Grabe+M%22">Grabe M</searchLink>; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stroud+RM%22">Stroud RM</searchLink>; Department of Biochemistry and Biophysics, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu.; Department of Pharmaceutical Chemistry, UCSF School of Medicine, San Francisco, CA, USA. stroud@msg.ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Edwards+RH%22">Edwards RH</searchLink>; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA. robert.edwards@ucsf.edu.
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