Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.

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Title: Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.
Authors: Cai Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zhao P; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven 3000, Belgium.; Department of Oncology, KU Leuven, Leuven 3000, Belgium., Wu F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zhao H; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Shao H; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Marra A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Patel P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., O'Connell E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Fink E; Department of Cancer Biology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA., Miele MM; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Li Z; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., De Stanchina E; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Cocco E; Department of Biochemistry and Molecular Biology/Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA., Razavi P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Toska E; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA., Fanning SW; Department of Cancer Biology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA., Xu G; National Institute of Biological Sciences (NIBS), Beijing 102206, China., Sablina AA; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven 3000, Belgium.; Department of Oncology, KU Leuven, Leuven 3000, Belgium., Scaltriti M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Chandarlapaty S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jun 04; Vol. 17 (801), pp. eadk7786. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.
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  Data: <searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven 3000, Belgium.; Department of Oncology, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Wu+F%22">Wu F</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Shao+H%22">Shao H</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Marra+A%22">Marra A</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22O'Connell+E%22">O'Connell E</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Fink+E%22">Fink E</searchLink>; Department of Cancer Biology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA.<br /><searchLink fieldCode="AU" term="%22Miele+MM%22">Miele MM</searchLink>; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Proteomics Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22De+Stanchina+E%22">De Stanchina E</searchLink>; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Cocco+E%22">Cocco E</searchLink>; Department of Biochemistry and Molecular Biology/Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.<br /><searchLink fieldCode="AU" term="%22Razavi+P%22">Razavi P</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Toska+E%22">Toska E</searchLink>; Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Fanning+SW%22">Fanning SW</searchLink>; Department of Cancer Biology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA.<br /><searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; National Institute of Biological Sciences (NIBS), Beijing 102206, China.<br /><searchLink fieldCode="AU" term="%22Sablina+AA%22">Sablina AA</searchLink>; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven 3000, Belgium.; Department of Oncology, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Scaltriti+M%22">Scaltriti M</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chandarlapaty+S%22">Chandarlapaty S</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Jun 04; Vol. 17 (801), pp. eadk7786. <i>Date of Electronic Publication: </i>2025 Jun 04.
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