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Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.

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Title: Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.
Authors: Mulholland EJ; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Belnoue-Davis HL; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK. hayley.davis@well.ox.ac.uk., Valbuena GN; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Gunduz N; Cancer Research UK Scotland Centre, Glasgow, UK., Ligeza A; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Lin M; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Biswas S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Gil Vasquez E; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Omwenga S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Nasreddin N; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Hodder MC; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Wang LM; Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore., Ng AS; Department of Oncology, University of Oxford, Oxford, UK., Jennings E; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK., Midwood KS; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK., Dedi N; UK Research, UCB Pharma, Slough, Berkshire, UK., Irshad S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Ridgway RA; Cancer Research UK Scotland Centre, Glasgow, UK., Phesse TJ; Department of Oncology, University of Oxford, Oxford, UK.; The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK., East J; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK., Tomlinson IP; Department of Oncology, University of Oxford, Oxford, UK., Davies GC; UK Research, UCB Pharma, Slough, Berkshire, UK., Sansom OJ; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Leedham SJ; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK.
Source: Nature communications [Nat Commun] 2025 Jun 04; Vol. 16 (1), pp. 5167. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.
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  Data: <searchLink fieldCode="AU" term="%22Mulholland+EJ%22">Mulholland EJ</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Belnoue-Davis+HL%22">Belnoue-Davis HL</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK. hayley.davis@well.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Valbuena+GN%22">Valbuena GN</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gunduz+N%22">Gunduz N</searchLink>; Cancer Research UK Scotland Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ligeza+A%22">Ligeza A</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Biswas+S%22">Biswas S</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gil+Vasquez+E%22">Gil Vasquez E</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Omwenga+S%22">Omwenga S</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Nasreddin+N%22">Nasreddin N</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hodder+MC%22">Hodder MC</searchLink>; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Wang+LM%22">Wang LM</searchLink>; Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ng+AS%22">Ng AS</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jennings+E%22">Jennings E</searchLink>; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Midwood+KS%22">Midwood KS</searchLink>; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dedi+N%22">Dedi N</searchLink>; UK Research, UCB Pharma, Slough, Berkshire, UK.<br /><searchLink fieldCode="AU" term="%22Irshad+S%22">Irshad S</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ridgway+RA%22">Ridgway RA</searchLink>; Cancer Research UK Scotland Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Phesse+TJ%22">Phesse TJ</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.; The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22East+J%22">East J</searchLink>; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tomlinson+IP%22">Tomlinson IP</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Davies+GC%22">Davies GC</searchLink>; UK Research, UCB Pharma, Slough, Berkshire, UK.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Leedham+SJ%22">Leedham SJ</searchLink>; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK.
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