Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.
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| Title: | Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling. |
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| Authors: | Mulholland EJ; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Belnoue-Davis HL; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK. hayley.davis@well.ox.ac.uk., Valbuena GN; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Gunduz N; Cancer Research UK Scotland Centre, Glasgow, UK., Ligeza A; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Lin M; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Biswas S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Gil Vasquez E; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Omwenga S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Nasreddin N; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK., Hodder MC; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Wang LM; Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore., Ng AS; Department of Oncology, University of Oxford, Oxford, UK., Jennings E; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK., Midwood KS; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science University of Oxford, Oxford, UK., Dedi N; UK Research, UCB Pharma, Slough, Berkshire, UK., Irshad S; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Ridgway RA; Cancer Research UK Scotland Centre, Glasgow, UK., Phesse TJ; Department of Oncology, University of Oxford, Oxford, UK.; The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK., East J; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK., Tomlinson IP; Department of Oncology, University of Oxford, Oxford, UK., Davies GC; UK Research, UCB Pharma, Slough, Berkshire, UK., Sansom OJ; Cancer Research UK Scotland Centre, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Leedham SJ; Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK. |
| Source: | Nature communications [Nat Commun] 2025 Jun 04; Vol. 16 (1), pp. 5167. Date of Electronic Publication: 2025 Jun 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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