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Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.

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Bibliographic Details
Title: Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.
Authors: Adeshakin AO; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Shi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Perry SS; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Sheppard H; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Nguyen P; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Sun X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Zhou P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Métais JY; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Cunningham T; Flow Cytometry and Cell Sorting Shared Resource, St. Jude Children's Research Hospital, Memphis, TN., Anil KC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Tian L; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Peche V; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Prater MS; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN., Langfitt DM; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN., Yustein JT; Aflac Cancer and Blood Disorders Center and the Winship Cancer Institute, Emory University, Atlanta, GA., Krenciute G; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., DeRenzo C; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Chi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Gottschalk S; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 23. Date of Electronic Publication: 2025 May 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.05.20.650777