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Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.

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Title: Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.
Authors: Adeshakin AO; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Shi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Perry SS; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Sheppard H; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Nguyen P; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Sun X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Zhou P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Métais JY; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Cunningham T; Flow Cytometry and Cell Sorting Shared Resource, St. Jude Children's Research Hospital, Memphis, TN., Anil KC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Tian L; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Peche V; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Prater MS; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN., Langfitt DM; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN., Yustein JT; Aflac Cancer and Blood Disorders Center and the Winship Cancer Institute, Emory University, Atlanta, GA., Krenciute G; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., DeRenzo C; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN., Chi H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN., Gottschalk S; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 23. Date of Electronic Publication: 2025 May 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting Regnase-1 unleashes CAR T cell antitumor activity for osteosarcoma and creates a proinflammatory tumor microenvironment.
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  Data: <searchLink fieldCode="AU" term="%22Adeshakin+AO%22">Adeshakin AO</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Perry+SS%22">Perry SS</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Sheppard+H%22">Sheppard H</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Nguyen+P%22">Nguyen P</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Métais+JY%22">Métais JY</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Cunningham+T%22">Cunningham T</searchLink>; Flow Cytometry and Cell Sorting Shared Resource, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Anil+KC%22">Anil KC</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Tian+L%22">Tian L</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Peche+V%22">Peche V</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Prater+MS%22">Prater MS</searchLink>; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Langfitt+DM%22">Langfitt DM</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Pruett-Miller+SM%22">Pruett-Miller SM</searchLink>; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Yustein+JT%22">Yustein JT</searchLink>; Aflac Cancer and Blood Disorders Center and the Winship Cancer Institute, Emory University, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Krenciute+G%22">Krenciute G</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22DeRenzo+C%22">DeRenzo C</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Chi+H%22">Chi H</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Gottschalk+S%22">Gottschalk S</searchLink>; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 May 23. <i>Date of Electronic Publication: </i>2025 May 23.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1101/2025.05.20.650777
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        Text: English
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