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Unlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation.

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Title: Unlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation.
Authors: Park W; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea., Son SY; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea., Yi J; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea., Cha S; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea., Moon H; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea., Kim M; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea., Ji S; Department of Brain Sciences, DGIST, Daegu 42988, Republic of Korea., Yu W; Department of Brain Sciences, DGIST, Daegu 42988, Republic of Korea., Sung C; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Cha SS; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Republic of Korea., Hahn JS; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Jun 06; Vol. 53 (11).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Unlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation.
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  Data: <searchLink fieldCode="AU" term="%22Park+W%22">Park W</searchLink>; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+SY%22">Son SY</searchLink>; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yi+J%22">Yi J</searchLink>; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cha+S%22">Cha S</searchLink>; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Moon+H%22">Moon H</searchLink>; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ji+S%22">Ji S</searchLink>; Department of Brain Sciences, DGIST, Daegu 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yu+W%22">Yu W</searchLink>; Department of Brain Sciences, DGIST, Daegu 42988, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Sung+C%22">Sung C</searchLink>; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cha+SS%22">Cha SS</searchLink>; Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hahn+JS%22">Hahn JS</searchLink>; Department of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%220411011%22">Nucleic acids research</searchLink> [Nucleic Acids Res] 2025 Jun 06; Vol. 53 (11).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0411011 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1362-4962 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203051048%22">03051048 </searchLink><i>NLM ISO Abbreviation: </i>Nucleic Acids Res <i>Subsets: </i>MEDLINE
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        Value: 10.1093/nar/gkaf462
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            – D: 06
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              Text: 2025 Jun 06
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              Y: 2025
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