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Rational synthesis, activity and mechanism insights of a new aminoquinoline salt against malaria parasites: in vitro and in vivo approaches.

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Title: Rational synthesis, activity and mechanism insights of a new aminoquinoline salt against malaria parasites: in vitro and in vivo approaches.
Authors: de Oliveira BA; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Raimundo FO; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., de Paula WT; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Bezerra Bellei JC; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Glanzmann N; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Machado LF; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., da Fonseca AL; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil., Freitas CS; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., da Costa Nunes IK; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil., Neto AF; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Rocha VN; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Pereira HMG; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil., Coelho EAF; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., de Pilla Varotti F; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil., Scopel KKG; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: keziagscopel@gmail.com., da Silva AD; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: david.silva@ufjf.br.
Source: Chemico-biological interactions [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111588. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22de+Oliveira+BA%22">de Oliveira BA</searchLink>; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Raimundo+FO%22">Raimundo FO</searchLink>; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Paula+WT%22">de Paula WT</searchLink>; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Bezerra+Bellei+JC%22">Bezerra Bellei JC</searchLink>; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Glanzmann+N%22">Glanzmann N</searchLink>; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+LF%22">Machado LF</searchLink>; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Fonseca+AL%22">da Fonseca AL</searchLink>; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Freitas+CS%22">Freitas CS</searchLink>; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Costa+Nunes+IK%22">da Costa Nunes IK</searchLink>; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil.<br /><searchLink fieldCode="AU" term="%22Neto+AF%22">Neto AF</searchLink>; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Rocha+VN%22">Rocha VN</searchLink>; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Pereira+HMG%22">Pereira HMG</searchLink>; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil.<br /><searchLink fieldCode="AU" term="%22Coelho+EAF%22">Coelho EAF</searchLink>; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Pilla+Varotti+F%22">de Pilla Varotti F</searchLink>; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Scopel+KKG%22">Scopel KKG</searchLink>; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: keziagscopel@gmail.com.<br /><searchLink fieldCode="AU" term="%22da+Silva+AD%22">da Silva AD</searchLink>; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: david.silva@ufjf.br.
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