Rational synthesis, activity and mechanism insights of a new aminoquinoline salt against malaria parasites: in vitro and in vivo approaches.
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| Title: | Rational synthesis, activity and mechanism insights of a new aminoquinoline salt against malaria parasites: in vitro and in vivo approaches. |
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| Authors: | de Oliveira BA; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Raimundo FO; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., de Paula WT; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Bezerra Bellei JC; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Glanzmann N; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Machado LF; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., da Fonseca AL; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil., Freitas CS; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., da Costa Nunes IK; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil., Neto AF; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Rocha VN; Research Centre of Pathology and Veterinary Histology. Department of Veterinary Medicine, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil., Pereira HMG; Technological Development Support Laboratory, Chemistry Hub, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21.941-598, Brazil., Coelho EAF; Post-graduation Program in Health Sciences, Infectology and Tropical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil., de Pilla Varotti F; Research Center on Biological Chemistry (NQBio), Federal University of São João Del Rei, Divinópolis, MG, Minas Gerais, Brazil., Scopel KKG; Research Centre of Parasitology (NUPEP). Department of Parasitology, Microbiology and Immunology and Post-Graduate Program in Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: keziagscopel@gmail.com., da Silva AD; Multifunctional Center for Chemical Research (NUPEQ), Department of Chemistry, Institute of Exact Science, Federal University of Juiz de Fora, Juiz de Fora, MG, 36.036-900, Brazil. Electronic address: david.silva@ufjf.br. |
| Source: | Chemico-biological interactions [Chem Biol Interact] 2025 Sep 05; Vol. 418, pp. 111588. Date of Electronic Publication: 2025 Jun 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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