Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.

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Title: Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.
Authors: Woudenberg T; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van der Bent ML; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van den Homberg DAL; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Nguyen TTM; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Wermer MJH; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Department of Neurology, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., van den Wijngaard IR; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.; Neurology, Haaglanden Medical Center, 2501 CK The Hague, the Netherlands., Quax PHA; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Nossent AY; Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark., Kruyt ND; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2025 May 05; Vol. 36 (2), pp. 102553. Date of Electronic Publication: 2025 May 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2162-2531
DOI:10.1016/j.omtn.2025.102553