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Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.

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Title: Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.
Authors: Woudenberg T; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van der Bent ML; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., van den Homberg DAL; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Nguyen TTM; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Wermer MJH; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Department of Neurology, University Medical Center Groningen, 9700 RB Groningen, the Netherlands., van den Wijngaard IR; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.; Neurology, Haaglanden Medical Center, 2501 CK The Hague, the Netherlands., Quax PHA; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands., Nossent AY; Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark., Kruyt ND; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.
Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2025 May 05; Vol. 36 (2), pp. 102553. Date of Electronic Publication: 2025 May 05 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE
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  Data: Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods.
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  Data: <searchLink fieldCode="AU" term="%22Woudenberg+T%22">Woudenberg T</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Bent+ML%22">van der Bent ML</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Homberg+DAL%22">van den Homberg DAL</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nguyen+TTM%22">Nguyen TTM</searchLink>; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wermer+MJH%22">Wermer MJH</searchLink>; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Department of Neurology, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Wijngaard+IR%22">van den Wijngaard IR</searchLink>; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.; Neurology, Haaglanden Medical Center, 2501 CK The Hague, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Quax+PHA%22">Quax PHA</searchLink>; Department of Vascular Surgery, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nossent+AY%22">Nossent AY</searchLink>; Department of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kruyt+ND%22">Kruyt ND</searchLink>; Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.; University Neurovascular Center Leiden-The Hague, 2300 RC Leiden, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101581621%22">Molecular therapy. Nucleic acids</searchLink> [Mol Ther Nucleic Acids] 2025 May 05; Vol. 36 (2), pp. 102553. <i>Date of Electronic Publication: </i>2025 May 05 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101581621 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2162-2531 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221622531%22">21622531 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther Nucleic Acids <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 May 05
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