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Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.

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Title: Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.
Authors: Meister J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany., Wanka L; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany., Perry-Hauser NA; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Liu L; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States., Iverson TM; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Gurevich VV; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Beck-Sickinger AG; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States., Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.
Source: Biochemistry [Biochemistry] 2025 Jul 01; Vol. 64 (13), pp. 2727-2736. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of Mutant M<subscript>3</subscript> Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.
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  Data: <searchLink fieldCode="AU" term="%22Meister+J%22">Meister J</searchLink>; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Wanka+L%22">Wanka L</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany.<br /><searchLink fieldCode="AU" term="%22Perry-Hauser+NA%22">Perry-Hauser NA</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.<br /><searchLink fieldCode="AU" term="%22Iverson+TM%22">Iverson TM</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Gurevich+VV%22">Gurevich VV</searchLink>; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Beck-Sickinger+AG%22">Beck-Sickinger AG</searchLink>; Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Leipzig 04109, Germany.<br /><searchLink fieldCode="AU" term="%22Kruse+AC%22">Kruse AC</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Wess+J%22">Wess J</searchLink>; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, United States.
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  Data: <searchLink fieldCode="JN" term="%220370623%22">Biochemistry</searchLink> [Biochemistry] 2025 Jul 01; Vol. 64 (13), pp. 2727-2736. <i>Date of Electronic Publication: </i>2025 Jun 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370623 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4995 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062960%22">00062960 </searchLink><i>NLM ISO Abbreviation: </i>Biochemistry <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.biochem.5c00036
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        Text: English
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              Text: 2025 Jul 01
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