Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC.
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| Title: | Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC. |
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| Authors: | Liu S; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Li L; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Zhang F; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Rheumatology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Garcia-Corral M; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Meyer K; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Fortuna PRJ; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., van Sambeek B; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Radboud University, Nijmegen, the Netherlands., Appleton E; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Ng AHM; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; GC Therapeutics, Inc, Cambridge, MA, USA., Khoshakhlagh P; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; GC Therapeutics, Inc, Cambridge, MA, USA., Lu YR; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Cameron J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Ramirez RN; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Chen Y; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Wu CT; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Huang JY; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Tan Y; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chao G; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Aach J; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Lim ET; Department of Medicine, Division of Innate Immunity University of Massachusetts Chan Medical School, Worcester, MA, USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Tam JM; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. jenny.tam@wyss.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. jenny.tam@wyss.harvard.edu., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK. soumya@broadinstitute.org., Church GM; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. gchurch@genetics.med.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2025 Jun 10; Vol. 16 (1), pp. 5136. Date of Electronic Publication: 2025 Jun 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-59596-3 |
