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AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.

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Title: AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.
Authors: Saadallah K; CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité, Paris, France.; CytoMorpho Lab, Chimie Biologie Innovation (CBI), UMR 8231, Ecole Supérieure de Physique et Chimie Industrielle de la Ville de Paris (ESPCI), Institute Pierre-Gilles de Gennes, Paris, France., Vianay B; CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité, Paris, France.; CytoMorpho Lab, Chimie Biologie Innovation (CBI), UMR 8231, Ecole Supérieure de Physique et Chimie Industrielle de la Ville de Paris (ESPCI), Institute Pierre-Gilles de Gennes, Paris, France.; CytoMorpho Lab, Laboratory of Cellular and Vegetal Physiology, UMR 5168, CEA, INRA, CNRS, University of Grenoble-Alpes, Interdisciplinary Research Institute of Grenoble, Grenoble, France., Bonnemay L; CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité, Paris, France.; CytoMorpho Lab, Chimie Biologie Innovation (CBI), UMR 8231, Ecole Supérieure de Physique et Chimie Industrielle de la Ville de Paris (ESPCI), Institute Pierre-Gilles de Gennes, Paris, France.; CytoMorpho Lab, Laboratory of Cellular and Vegetal Physiology, UMR 5168, CEA, INRA, CNRS, University of Grenoble-Alpes, Interdisciplinary Research Institute of Grenoble, Grenoble, France., Pasquer H; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France.; Centre d'Investigation Clinique INSERM 1427, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France., Kelly L; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France., Mathis S; Department of Hematology and Immunology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France., Culeux C; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France., Marie R; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France., Meslin PA; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France., Fodil S; Department of Hematology and Immunology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France., Chaintreuil P; INSERM Unit 1065, Mediterranean Center of Molecular Medicine (C3M), University of Côte d'Azur, Nice, France., Kerreneur E; INSERM Unit 1065, Mediterranean Center of Molecular Medicine (C3M), University of Côte d'Azur, Nice, France., Jacquel A; INSERM Unit 1065, Mediterranean Center of Molecular Medicine (C3M), University of Côte d'Azur, Nice, France., Raffoux E; Department of Hematology and Immunology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France., Nizard R; Service de chirurgie orthopédique et traumatologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France., Lobry C; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France., Blanchoin L; CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité, Paris, France.; CytoMorpho Lab, Chimie Biologie Innovation (CBI), UMR 8231, Ecole Supérieure de Physique et Chimie Industrielle de la Ville de Paris (ESPCI), Institute Pierre-Gilles de Gennes, Paris, France.; CytoMorpho Lab, Laboratory of Cellular and Vegetal Physiology, UMR 5168, CEA, INRA, CNRS, University of Grenoble-Alpes, Interdisciplinary Research Institute of Grenoble, Grenoble, France., Benajiba L; INSERM U944, Institut de Recherche Saint Louis (IRSL), Université Paris Cité, Paris, France.; Centre d'Investigation Clinique INSERM 1427, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Cité, Paris, France., Théry M; CytoMorpho Lab, Human Immunology Pathophysiology Immunotherapy (HIPI), U976, Institut de Recherche Saint Louis (IRSL), Hôpital Saint Louis, Université Paris Cité, Paris, France. manuel.thery@cea.fr.; CytoMorpho Lab, Chimie Biologie Innovation (CBI), UMR 8231, Ecole Supérieure de Physique et Chimie Industrielle de la Ville de Paris (ESPCI), Institute Pierre-Gilles de Gennes, Paris, France. manuel.thery@cea.fr.; CytoMorpho Lab, Laboratory of Cellular and Vegetal Physiology, UMR 5168, CEA, INRA, CNRS, University of Grenoble-Alpes, Interdisciplinary Research Institute of Grenoble, Grenoble, France. manuel.thery@cea.fr.
Source: EMBO reports [EMBO Rep] 2025 Jul; Vol. 26 (13), pp. 3264-3279. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1469-3178
DOI:10.1038/s44319-025-00466-w