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Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.

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Title: Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
Authors: Yin X; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China., Pu Y; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America., Yuan S; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Pache L; NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America., Churas C; Department of Medicine, University of California San Diego, La Jolla, California, United States of America., Weston S; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Riva L; Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America., Simons LM; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America., Cisneros WJ; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America., Clausen T; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America., Biddle G; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Doss-Gollin S; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Deming M; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., De Jesus PD; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America., Kim HN; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia., Fuentes D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America., Whitelock JM; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia., Esko JD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America., Lord MS; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia., Mena I; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Tisch Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America., Hultquist JF; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America., Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Ideker T; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, United States of America., Pratt D; Department of Medicine, University of California San Diego, La Jolla, California, United States of America., Martin-Sancho L; Department of Infectious Disease, Imperial College London, London, United Kingdom., Chanda SK; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America.
Source: PLoS biology [PLoS Biol] 2025 Jun 12; Vol. 23 (6), pp. e3002738. Date of Electronic Publication: 2025 Jun 12 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
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  Data: Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
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  Data: <searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Pu+Y%22">Pu Y</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Yuan+S%22">Yuan S</searchLink>; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Pache+L%22">Pache L</searchLink>; NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Churas+C%22">Churas C</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Weston+S%22">Weston S</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Riva+L%22">Riva L</searchLink>; Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Simons+LM%22">Simons LM</searchLink>; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Cisneros+WJ%22">Cisneros WJ</searchLink>; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Clausen+T%22">Clausen T</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Biddle+G%22">Biddle G</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Doss-Gollin+S%22">Doss-Gollin S</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Deming+M%22">Deming M</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22De+Jesus+PD%22">De Jesus PD</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Kim+HN%22">Kim HN</searchLink>; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Fuentes+D%22">Fuentes D</searchLink>; 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Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Tisch Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.<br /><searchLink fieldCode="AU" term="%22Hultquist+JF%22">Hultquist JF</searchLink>; Division of Infectious Diseases, Departments of Medicine and Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Frieman+MB%22">Frieman MB</searchLink>; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.<br /><searchLink fieldCode="AU" term="%22Ideker+T%22">Ideker T</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Pratt+D%22">Pratt D</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Martin-Sancho+L%22">Martin-Sancho L</searchLink>; Department of Infectious Disease, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chanda+SK%22">Chanda SK</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.; Calibr-Skaggs at Scripps Research Institute, La Jolla, California, United States of America.
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