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Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition.

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Title: Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition.
Authors: Fischer J; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany. julia.fischer2@ukmuenster.de.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. julia.fischer2@ukmuenster.de.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany. julia.fischer2@ukmuenster.de.; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany. julia.fischer2@ukmuenster.de., Rusyn L; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany., Krus F; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany., Lobastova L; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Herb M; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany., Gluschko A; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany., Hejazi Z; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Hos NJ; Department of Clinical Research, Clinic of Infectious Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, United Kingdom., Calabrese C; Max Planck Institute for Biology of Ageing, Cologne, Germany., Stemler J; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Department II of Internal Medicine, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany., Mayer P; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany., Hanssen R; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Policlinic for Endocrinology, Diabetes and Preventive Medicine, Cologne, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany., Theobald SJ; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Vehreschild JJ; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Department II of Internal Medicine, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany., Trebicka J; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany.; European Foundation for the Study of Chronic Liver Failure - EF Clif, Barcelona, Spain.; Institute for Bioengineering of Catalonia, Barcelona, Spain.; Department of Medical Gastroenterology and Hepatology, University of Southern Denmark, Odense, Denmark., Krönke M; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany., Fries JWU; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Pathology, University of Cologne, Cologne, Germany., Lehmann C; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Nguyen PH; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Rybniker J; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Robinson N; Center for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia., Seeger-Nukpezah T; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany. tamina.seeger-nukpezah@uk-koeln.de.
Source: Cell death & disease [Cell Death Dis] 2025 Jun 12; Vol. 16 (1), pp. 445. Date of Electronic Publication: 2025 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Fischer+J%22">Fischer J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany. julia.fischer2@ukmuenster.de.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. julia.fischer2@ukmuenster.de.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany. julia.fischer2@ukmuenster.de.; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany. julia.fischer2@ukmuenster.de.<br /><searchLink fieldCode="AU" term="%22Rusyn+L%22">Rusyn L</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Krus+F%22">Krus F</searchLink>; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Lobastova+L%22">Lobastova L</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Herb+M%22">Herb M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gluschko+A%22">Gluschko A</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hejazi+Z%22">Hejazi Z</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hos+NJ%22">Hos NJ</searchLink>; Department of Clinical Research, Clinic of Infectious Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Calabrese+C%22">Calabrese C</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stemler+J%22">Stemler J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Department II of Internal Medicine, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer+P%22">Mayer P</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hanssen+R%22">Hanssen R</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Policlinic for Endocrinology, Diabetes and Preventive Medicine, Cologne, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Theobald+SJ%22">Theobald SJ</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Vehreschild+JJ%22">Vehreschild JJ</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Department II of Internal Medicine, Hematology/Oncology and Infectious Diseases, University Hospital of Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Trebicka+J%22">Trebicka J</searchLink>; University of Münster, Faculty of Medicine and University Hospital of Münster, Department of Internal Medicine B, Albert-Schweitzer-Campus, Münster, Germany.; European Foundation for the Study of Chronic Liver Failure - EF Clif, Barcelona, Spain.; Institute for Bioengineering of Catalonia, Barcelona, Spain.; Department of Medical Gastroenterology and Hepatology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Krönke+M%22">Krönke M</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Medical Microbiology, Immunology and Hygiene, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fries+JWU%22">Fries JWU</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Institute of Pathology, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+C%22">Lehmann C</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+PH%22">Nguyen PH</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Chair Translational Research, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Rybniker+J%22">Rybniker J</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Robinson+N%22">Robinson N</searchLink>; Center for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Seeger-Nukpezah+T%22">Seeger-Nukpezah T</searchLink>; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology, Cologne, Germany. tamina.seeger-nukpezah@uk-koeln.de.
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