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Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma.

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Title: Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma.
Authors: Bouska A; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Zhang W; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Sharma S; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Holte H; Department of Oncology, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for B-Cell Malignancies, Oslo, Norway., Shah RA; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Lone WG; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Soma MA; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Yang R; Department of Pathology, City of Hope National Medical Center, Duarte, California, USA., Liu X; Department of Pathology, City of Hope National Medical Center, Duarte, California, USA., Mehmood S; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Chawla RS; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Cappelli LV; Department of Pathology and Laboratory Medicine, Weil Cornell Medical College, New York, New York, USA., Fiore D; Department of Pathology and Laboratory Medicine, Weil Cornell Medical College, New York, New York, USA.; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy., Gong Q; Department of Pathology, City of Hope National Medical Center, Duarte, California, USA., Heavican-Foral TB; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Cannatella JJ; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Amador C; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA., Arif A; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Smith LM; Department of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA., Lim ST; Division of Medical Oncology, National Cancer Centre Singapore/Duke-NUS Medical School, Singapore, Singapore., Ong CK; Division of Medical Oncology, National Cancer Centre Singapore/Duke-NUS Medical School, Singapore, Singapore., Feldman AL; Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Du MQ; Department of Pathology, University of Cambridge, Cambridge, UK., Perry AM; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA., de Leval L; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Greiner TC; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Fu K; Department of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA., Trøen G; Department of Pathology, Oslo University Hospital, Oslo, Norway., Vodák D; Department of Pathology, Oslo University Hospital, Oslo, Norway., Nakken S; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.; Center for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway., Delabie J; Toronto General Hospital: University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada., Weinstock D; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA., Pileri S; European Institute of Oncology IRCCS, Milan, Italy.; Bologna University School of Medicine, Bologna, Italy., Laginestra A; European Institute of Oncology IRCCS, Milan, Italy., Kim K; Department of Biomedical Sciences, College of Medicine, Inha University, Incheon, Republic of Korea.; Program in Biomedical Science & Engineering, Inha University, Incheon, Republic of Korea.; Research Center for Controlling Intercellular Communication (RCIC), College of Medicine, Inha University, Incheon, Republic of Korea., Pajvani U; Department of Medicine, Columbia University, New York, New York, USA., Vose JM; Department of Hematology and Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Weisenburger DD; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Horwitz SM; Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Dave S; Department of Medicine, Duke University, Durham, North Carolina, USA., Khoury J; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Inghirami G; Department of Pathology and Laboratory Medicine, Weil Cornell Medical College, New York, New York, USA., Chan WC; Department of Pathology, City of Hope National Medical Center, Duarte, California, USA., Iqbal J; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Source: American journal of hematology [Am J Hematol] 2025 Sep; Vol. 100 (9), pp. 1486-1501. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-8652 (Electronic) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma.
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Department of Pathology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nakken+S%22">Nakken S</searchLink>; Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.; Center for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Delabie+J%22">Delabie J</searchLink>; Toronto General Hospital: University Health Network (UHN), University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Weinstock+D%22">Weinstock D</searchLink>; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pileri+S%22">Pileri S</searchLink>; European Institute of Oncology IRCCS, Milan, Italy.; Bologna University School of Medicine, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Laginestra+A%22">Laginestra A</searchLink>; 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