Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes.

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Title: Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes.
Authors: Mix MR; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Kreitlow BL; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Berton RR; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Xu J; Department of Urology, University of Minnesota Medical School, Minneapolis, MN, USA., Fain CE; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., van de Wall S; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Pewe LL; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Hancox LS; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Hassert MA; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Kannan SK; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Arumugam SA; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Sievers CM; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Buchanan GF; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Griffith TS; Department of Urology, University of Minnesota Medical School, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.; Minneapolis VA Health Care System, Minneapolis, MN, USA., Badovinac VP; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.; Department of Pathology Graduate Programs, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Harty JT; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. john-harty@uiowa.edu.; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA. john-harty@uiowa.edu.; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA. john-harty@uiowa.edu.; Department of Pathology Graduate Programs, University of Iowa Carver College of Medicine, Iowa City, IA, USA. john-harty@uiowa.edu.
Source: Nature immunology [Nat Immunol] 2025 Jul; Vol. 26 (7), pp. 1087-1098. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-025-02174-y