Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity.
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| Title: | Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity. |
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| Authors: | Moscoso A; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, Spain., Heeman F; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Raghavan S; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Costoya-Sánchez A; Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, Spain.; Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain., van Essen M; Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Mainta I; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland., Camacho V; Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Rodríguez-Fonseca O; Nuclear Medicine Department, Lucus Augusti University Hospital, Lugo, Spain., Silva-Rodríguez J; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Reina Sofía Alzheimer's Centre, CIEN Foundation, Instituto de Salud Carlos III, Madrid, Spain., Perissinotti A; Nuclear Medicine Department, Hospital Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain.; Biomedical Research Networking Centre of Bioengineering, Biomaterials, and Nanomedicine, Instituto de Salud Carlos III, Barcelona, Spain., Gu Y; Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea., Yun J; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Peretti D; Laboratory of Neuroimaging and Innovative Molecular Tracers, Faculty of Medicine, Geneva University Neurocenter, University of Geneva, Geneva, Switzerland., Ribaldi F; Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Neuroimaging of Aging, University of Geneva, Geneva, Switzerland., Coomans EM; Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, University Medical Center, Amsterdam, the Netherlands., Brum WS; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Grothe MJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Reina Sofía Alzheimer's Centre, CIEN Foundation, Instituto de Salud Carlos III, Madrid, Spain., Aguiar P; Nuclear Medicine Department and Molecular Imaging Group, Instituto de Investigación Sanitaria de Santiago de Compostela, Travesía da Choupana s/n, Santiago de Compostela, Spain.; Molecular Imaging and Pharmacokinetic Modelling Group, Center for Research in Molecular Medicine and Chronic Diseases, University of Santiago de Compostela, Spain., Bischof GN; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; Research Center Juelich, Institute for Neuroscience and Medicine II, Molecular Organization of the Brain, Juelich, Germany., Drzezga A; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.; Research Center Juelich, Institute for Neuroscience and Medicine II, Molecular Organization of the Brain, Juelich, Germany.; German Center for Neurodegenerative Diseases, Bonn-Cologne, Germany., Seo SW; Samsung Alzheimer Research Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea.; Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Science & Technology, Sungkyunkwan University, Seoul, Korea.; Department of Health Science and Technology, Samsung Advanced Institute for Health Science & Technology, Sungkyunkwan University, Seoul, Korea., Villeneuve S; McConnell Brain Imaging Centre, McGill University, Montreal, Quebec, Canada.; Douglas Mental Health University Institute-Research Center, Verdun, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Malpetti M; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, United Kingdom.; UK Dementia Research Institute at University of Cambridge, Cambridge, United Kingdom., O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom., Rowe JB; Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, United Kingdom.; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom., van de Giessen EM; Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Ossenkoppele R; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, University Medical Center, Amsterdam, the Netherlands.; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Jagust WJ; Helen Wills Neuroscience Institute, University of California Berkeley., Smith R; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Lund University, Lund, Sweden., Frisoni GB; Geneva Memory Center, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland.; Laboratory of Neuroimaging of Aging, University of Geneva, Geneva, Switzerland., Garibotto V; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.; Laboratory of Neuroimaging and Innovative Molecular Tracers, Faculty of Medicine, Geneva University Neurocenter, University of Geneva, Geneva, Switzerland.; Centre d'Imagerie Biomedicale, Geneva, Switzerland., Soleimani-Meigooni DN; Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California., Carrillo M; Alzheimer's Association, Chicago, Illinois., Dickerson BC; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston., La Joie R; Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco., Rabinovici GD; Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco.; Department of Radiology and Biomedical Imaging, University of California San Francisco., Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis.; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis., LaMontagne PJ; Departments of Radiology, Washington University in St Louis School of Medicine, St Louis, Missouri.; Knight Alzheimer's Disease Research Center, Washington University in St Louis School of Medicine, St Louis, Missouri., Pontecorvo MJ; Avid, Eli Lilly and Company, Philadelphia, Pennsylvania., Johnson KA; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston.; Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, Massachusetts., Sperling RA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.; Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Boston, Massachusetts., Weiner MW; Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, California.; Department of Radiology and Biomedical Imaging, University of California San Francisco.; Department of Medicine, University of California San Francisco.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco.; Department of Neurology, University of California San Francisco., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Schöll M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.; Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom.; Department of Neuropsychiatry, Sahlgrenska University Hospital, Mölndal, Sweden. |
| Corporate Authors: | PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer’s Disease Neuroimaging Initiative |
| Source: | JAMA [JAMA] 2025 Jul 15; Vol. 334 (3), pp. 229-242. |
| Publication Type: | Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2025.7817 |
