Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology.

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Title: Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology.
Authors: Enomoto M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Masahiro.Enomoto@uhn.ca., Martinez-Valbuena I; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Forrest SL; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Xu X; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Munhoz RP; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada., Li J; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Lang AE; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada., Kovacs GG; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Krembil Brain Institute, University Health Network, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. gabor.kovacs@uhn.ca.; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. gabor.kovacs@uhn.ca.
Source: Communications biology [Commun Biol] 2025 Jun 16; Vol. 8 (1), pp. 929. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3642
DOI:10.1038/s42003-025-08355-7