In situ incorporation of boronate into carbonized alginate nanogels for targeted inhibition of triple-negative breast cancer metastasis by inducing cytoskeletal disruption, cell growth arrest, and apoptosis.

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Title: In situ incorporation of boronate into carbonized alginate nanogels for targeted inhibition of triple-negative breast cancer metastasis by inducing cytoskeletal disruption, cell growth arrest, and apoptosis.
Authors: Sarkar S; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Wang CY; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Hsu PH; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Unnikrishnan B; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Tang Y; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Chen SY; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Lin CJ; Institute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013, Taiwan., Anand A; Department of Biomedical Engineering, Chang Gang University, Taoyuan, 33302, Taiwan., Shih RH; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Hean LE; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan., Chen PY; Department of Neurosurgery, Chang Gung Memorial Hospital, Keelung, 20401, Taiwan; Department of General Surgery, Chang Gung Memorial Hospital, Keelung, 20401, Taiwan., Huang RY; Department of General Surgery, Chang Gung Memorial Hospital, Keelung, 20401, Taiwan., Chou CP; Department of Chemical Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. Electronic address: cpchou@uwaterloo.ca., Huang CC; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan; Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, 20224, Taiwan; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. Electronic address: huanging@ntou.edu.tw.
Source: Biomaterials [Biomaterials] 2026 Jan; Vol. 324, pp. 123500. Date of Electronic Publication: 2025 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1878-5905
DOI:10.1016/j.biomaterials.2025.123500