High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.

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Title: High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.
Authors: Aitken L; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K., Baillie G; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Pannifer A; Excientia, Oxford Science Park, The Schrödinger Building, Oxford OX4 4GE, U.K., Morrison A; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Major LL; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Alphey MS; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Sethi R; Glaxo Smith Kline Biologicals, rue de l'Institut 89, 1330 Rixensart, Belgium., Timmerman M; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands., Robinson J; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Riley J; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Shishikura Y; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Koekemoer L; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K., Von Delft F; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K., Rutjes H; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands., Read KD; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Jones PS; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., McElroy SP; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Smith TK; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K.; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Gunn-Moore FJ; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.
Source: ACS chemical biology [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1544-1559. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8937
DOI:10.1021/acschembio.5c00110