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High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.

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Title: High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.
Authors: Aitken L; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K., Baillie G; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Pannifer A; Excientia, Oxford Science Park, The Schrödinger Building, Oxford OX4 4GE, U.K., Morrison A; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Major LL; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Alphey MS; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Sethi R; Glaxo Smith Kline Biologicals, rue de l'Institut 89, 1330 Rixensart, Belgium., Timmerman M; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands., Robinson J; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Riley J; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Shishikura Y; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Koekemoer L; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K., Von Delft F; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K., Rutjes H; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands., Read KD; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K., Jones PS; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., McElroy SP; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Smith TK; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K.; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K., Gunn-Moore FJ; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.
Source: ACS chemical biology [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1544-1559. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Aitken+L%22">Aitken L</searchLink>; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K.<br /><searchLink fieldCode="AU" term="%22Baillie+G%22">Baillie G</searchLink>; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K.<br /><searchLink fieldCode="AU" term="%22Pannifer+A%22">Pannifer A</searchLink>; Excientia, Oxford Science Park, The Schrödinger Building, Oxford OX4 4GE, U.K.<br /><searchLink fieldCode="AU" term="%22Morrison+A%22">Morrison A</searchLink>; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K.<br /><searchLink fieldCode="AU" term="%22Major+LL%22">Major LL</searchLink>; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.<br /><searchLink fieldCode="AU" term="%22Alphey+MS%22">Alphey MS</searchLink>; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.<br /><searchLink fieldCode="AU" term="%22Sethi+R%22">Sethi R</searchLink>; Glaxo Smith Kline Biologicals, rue de l'Institut 89, 1330 Rixensart, Belgium.<br /><searchLink fieldCode="AU" term="%22Timmerman+M%22">Timmerman M</searchLink>; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Robinson+J%22">Robinson J</searchLink>; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Shishikura+Y%22">Shishikura Y</searchLink>; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Koekemoer+L%22">Koekemoer L</searchLink>; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K.<br /><searchLink fieldCode="AU" term="%22Von+Delft+F%22">Von Delft F</searchLink>; University of Oxford Centre for Medicines Discovery, Old Road Campus Research Building, Oxford OX3 7FZ, U.K.<br /><searchLink fieldCode="AU" term="%22Rutjes+H%22">Rutjes H</searchLink>; European Lead Factory, Pivot Park-Banting Building (RE600), Kloosterstraat 9, 5349 AB Oss, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Wellcome Centre of Anti-infectives Research, Drug Discovery Unit, University of Dundee School of Life Sciences, Dow Street, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Jones+PS%22">Jones PS</searchLink>; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K.<br /><searchLink fieldCode="AU" term="%22McElroy+SP%22">McElroy SP</searchLink>; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K.<br /><searchLink fieldCode="AU" term="%22Smith+TK%22">Smith TK</searchLink>; University of St. Andrews School of Chemistry, Biomolecular Sciences Building, North Haugh, St. Andrews KY16 9TF, U.K.; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.<br /><searchLink fieldCode="AU" term="%22Gunn-Moore+FJ%22">Gunn-Moore FJ</searchLink>; Biomedical Science Research Complex, University of St. Andrews School of Biology, North Haugh, St. Andrews KY16 9ST, U.K.
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  Data: <searchLink fieldCode="JN" term="%22101282906%22">ACS chemical biology</searchLink> [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1544-1559. <i>Date of Electronic Publication: </i>2025 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101282906 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1554-8937 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215548929%22">15548929 </searchLink><i>NLM ISO Abbreviation: </i>ACS Chem Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acschembio.5c00110
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              Text: 2025 Jul 18
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