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Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury.

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Title: Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury.
Authors: Valencia I; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Pastor-Martínez A; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Decouty-Pérez C; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Lopez-Rodriguez AB; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Álvarez-Rubal M; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Ramos E; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain., Calzaferri F; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; School of Chemical Science, Dublin City University (DCU), Dublin, Ireland., Zamorano-Fernández J; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Giner-García J; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Palpán-Flores AJ; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Rodríguez-Domínguez V; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Rodríguez de Cía J; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain., Hernández-García BJ; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain., Romero A; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain., de Los Ríos C; Department of Basic Health Sciences, School of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain.; High Performance Research Group in Physiopathology and Pharmacology of the Digestive System-Universidad Rey Juan Carlos (NeuGut-URJC), Alcorcón, Spain., Egea J; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Source: British journal of pharmacology [Br J Pharmacol] 2025 Oct; Vol. 182 (19), pp. 4693-4709. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
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  Data: Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury.
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  Data: <searchLink fieldCode="AU" term="%22Valencia+I%22">Valencia I</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor-Martínez+A%22">Pastor-Martínez A</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Decouty-Pérez+C%22">Decouty-Pérez C</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez-Rodriguez+AB%22">Lopez-Rodriguez AB</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Álvarez-Rubal+M%22">Álvarez-Rubal M</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ramos+E%22">Ramos E</searchLink>; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Calzaferri+F%22">Calzaferri F</searchLink>; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.; School of Chemical Science, Dublin City University (DCU), Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Zamorano-Fernández+J%22">Zamorano-Fernández J</searchLink>; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Giner-García+J%22">Giner-García J</searchLink>; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Palpán-Flores+AJ%22">Palpán-Flores AJ</searchLink>; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Domínguez+V%22">Rodríguez-Domínguez V</searchLink>; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez+de+Cía+J%22">Rodríguez de Cía J</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hernández-García+BJ%22">Hernández-García BJ</searchLink>; Service of Neurosurgery, Hospital Universitario La Paz, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Romero+A%22">Romero A</searchLink>; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22de+Los+Ríos+C%22">de Los Ríos C</searchLink>; Department of Basic Health Sciences, School of Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain.; High Performance Research Group in Physiopathology and Pharmacology of the Digestive System-Universidad Rey Juan Carlos (NeuGut-URJC), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Egea+J%22">Egea J</searchLink>; Laboratory of Molecular Neuroinflammation and Neuronal Plasticity, Research Unit, Hospital Universitario Santa Cristina. Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain.; Department of Pharmacology, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2025 Oct; Vol. 182 (19), pp. 4693-4709. <i>Date of Electronic Publication: </i>2025 Jun 18.
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