Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia.
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| Title: | Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer's disease dementia. |
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| Authors: | Hu T; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Liu Q; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA., Dai Q; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Tasaki S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Wang Y; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research On Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY10032, USA., Epstein MP; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Yang J; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA. jingjing.yang@emory.edu. |
| Source: | Alzheimer's research & therapy [Alzheimers Res Ther] 2025 Jun 18; Vol. 17 (1), pp. 135. Date of Electronic Publication: 2025 Jun 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1758-9193 |
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| DOI: | 10.1186/s13195-025-01774-y |
