Long read sequencing reveals transgene concatemerization and vector sequences integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes.
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| Title: | Long read sequencing reveals transgene concatemerization and vector sequences integration following AAV-driven electroporation of CRISPR RNP complexes in mouse zygotes. |
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| Authors: | Luqman MW; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; Khyber Medical University, Institute of Medical Sciences, Kohat, Pakistan., Jenjaroenpun P; Division of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Spathos J; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Shingte N; FOXG1 Research Foundation, New York, NY, United States., Cummins M; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, Australia., Nimsamer P; Division of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Ittner LM; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia., Wongsurawat T; Division of Medical Bioinformatics, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Delerue F; Dementia Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia. |
| Source: | Frontiers in genome editing [Front Genome Ed] 2025 Jun 04; Vol. 7, pp. 1582097. Date of Electronic Publication: 2025 Jun 04 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101775540 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-3439 (Electronic) Linking ISSN: 26733439 NLM ISO Abbreviation: Front Genome Ed Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2673-3439 |
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| DOI: | 10.3389/fgeed.2025.1582097 |
