BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.

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Title: BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.
Authors: Habich C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Kowalski A; Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany., Wachter A; AbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen, Germany., Heimann MJ; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Wolf M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Kummer MP; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Nicolaisen N; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Sliwinski C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Reinhardt L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Heil V; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Lange T; AbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen, Germany., Untucht C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Miller LN; AbbVie Inc., Pharmacology and Pathology, Lake County, IL 60064, USA., Korffmann J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Geist D; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Schöndorf D; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Lee H; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Bahnassawy L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Mielich-Süss B; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Brennan MS; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Wilkens R; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Röwe J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Weidling I; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Rudolf R; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany., Hafner M; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 69117 Heidelberg, Germany., Manos JD; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Cik M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Reinhardt P; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany. Electronic address: peter.reinhardt@abbvie.com.
Source: Stem cell reports [Stem Cell Reports] 2025 Jul 08; Vol. 20 (7), pp. 102539. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-6711
DOI:10.1016/j.stemcr.2025.102539