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BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.

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Title: BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.
Authors: Habich C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Kowalski A; Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany., Wachter A; AbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen, Germany., Heimann MJ; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Wolf M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Kummer MP; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Nicolaisen N; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Sliwinski C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Reinhardt L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Heil V; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Lange T; AbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen, Germany., Untucht C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Miller LN; AbbVie Inc., Pharmacology and Pathology, Lake County, IL 60064, USA., Korffmann J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Geist D; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Schöndorf D; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Lee H; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Bahnassawy L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Mielich-Süss B; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Brennan MS; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Wilkens R; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Röwe J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Weidling I; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Rudolf R; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany., Hafner M; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 69117 Heidelberg, Germany., Manos JD; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA., Cik M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany., Reinhardt P; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany. Electronic address: peter.reinhardt@abbvie.com.
Source: Stem cell reports [Stem Cell Reports] 2025 Jul 08; Vol. 20 (7), pp. 102539. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
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  Data: BMP, MEK, and WNT inhibition with NGN2 expression for rapid generation of hiPSC-derived neurons amenable to regional patterning.
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  Data: <searchLink fieldCode="AU" term="%22Habich+C%22">Habich C</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Kowalski+A%22">Kowalski A</searchLink>; Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Wachter+A%22">Wachter A</searchLink>; AbbVie Deutschland GmbH & Co. KG, Genomics Research Center, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Heimann+MJ%22">Heimann MJ</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+M%22">Wolf M</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Kummer+MP%22">Kummer MP</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Nicolaisen+N%22">Nicolaisen N</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Sliwinski+C%22">Sliwinski C</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+L%22">Reinhardt L</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Heil+V%22">Heil V</searchLink>; AbbVie Deutschland GmbH & Co. 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KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Brennan+MS%22">Brennan MS</searchLink>; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wilkens+R%22">Wilkens R</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Röwe+J%22">Röwe J</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Weidling+I%22">Weidling I</searchLink>; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Rudolf+R%22">Rudolf R</searchLink>; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Center for Mass Spectrometry and Optical Spectroscopy, Mannheim University of Applied Sciences, 68163 Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Hafner+M%22">Hafner M</searchLink>; Institute of Molecular and Cell Biology, Mannheim, University of Applied Sciences, D-68163 Mannheim, Germany, and Interdisciplinary Center for Neurosciences, Heidelberg, University, 69117 Heidelberg, Germany; Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Manos+JD%22">Manos JD</searchLink>; AbbVie Inc., Cambridge Research Center, 200 Sidney Street, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Cik+M%22">Cik M</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany.<br /><searchLink fieldCode="AU" term="%22Reinhardt+P%22">Reinhardt P</searchLink>; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen, Germany. Electronic address: peter.reinhardt@abbvie.com.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2025 Jul 08; Vol. 20 (7), pp. 102539. <i>Date of Electronic Publication: </i>2025 Jun 19.
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