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Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.

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Title: Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.
Authors: Schmidt SI; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Okarmus J; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Madsen DA; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Hansen JS; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Gregersen E; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Gram H; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark., Winkelmann LS; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Oliveira AS; Department of Materials and Production, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark., Heon-Roberts R; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Ryan BJ; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Freude K; Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen, Copenhagen, Denmark., Blaabjerg M; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; BRIDGE - Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Jensen PH; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark., Meyer M; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. mmeyer@health.sdu.dk.; Department of Neurology, Odense University Hospital, Odense, Denmark. mmeyer@health.sdu.dk.; BRIDGE - Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. mmeyer@health.sdu.dk.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Jun 21; Vol. 11 (1), pp. 180. Date of Electronic Publication: 2025 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
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  Data: Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons.
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  Data: <searchLink fieldCode="AU" term="%22Schmidt+SI%22">Schmidt SI</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Okarmus+J%22">Okarmus J</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Madsen+DA%22">Madsen DA</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+JS%22">Hansen JS</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Gregersen+E%22">Gregersen E</searchLink>; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Gram+H%22">Gram H</searchLink>; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Winkelmann+LS%22">Winkelmann LS</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Oliveira+AS%22">Oliveira AS</searchLink>; Department of Materials and Production, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Heon-Roberts+R%22">Heon-Roberts R</searchLink>; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ryan+BJ%22">Ryan BJ</searchLink>; Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Freude+K%22">Freude K</searchLink>; Faculty of Health and Medical Sciences, Department of Veterinary and Animal Sciences, Section for Pathobiological Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Blaabjerg+M%22">Blaabjerg M</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; BRIDGE - Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+PH%22">Jensen PH</searchLink>; DANDRITE, Danish Research Institute of Translational Neuroscience & Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Meyer+M%22">Meyer M</searchLink>; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. mmeyer@health.sdu.dk.; Department of Neurology, Odense University Hospital, Odense, Denmark. mmeyer@health.sdu.dk.; BRIDGE - Brain Research Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. mmeyer@health.sdu.dk.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2025 Jun 21; Vol. 11 (1), pp. 180. <i>Date of Electronic Publication: </i>2025 Jun 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101675390 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2373-8057 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223738057%22">23738057 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Parkinsons Dis <i>Subsets: </i>PubMed not MEDLINE
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