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Is highly purified cannabidiol a treatment opportunity for drug-resistant epilepsy in subjects with typical Rett syndrome and CDKL5 deficiency disorder?

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Title: Is highly purified cannabidiol a treatment opportunity for drug-resistant epilepsy in subjects with typical Rett syndrome and CDKL5 deficiency disorder?
Authors: Vignoli A; Childhood and Adolescence Neuropsychiatry Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Health Sciences Department, Università degli Studi di Milano, Milan, Italy., Prato G; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy., Alfei E; Pediatric Neurology Unit, Buzzi Children's Hospital, Milan, Italy., Bagnasco I; Division of Child Neuropsychiatry, Martini Hospital, Torino, Italy., Danieli A; Epilepsy Unit, IRCCS E. Medea Scientific Institute, Conegliano, Italy., Celario M; Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Favaro J; Department of Women's and Child's Health, University of Padua, Padova, Italy.; Paediatric Neurology and Neurophysiology Unit - University Hospital of Padua, Padova, Italy., Matricardi S; Department of Pediatrics, University of Chieti, Chieti, Italy., Operto FF; Department of Science of Health School of Medicine, University Magna Greacia of Catanzaro, Catanzaro, Italy., Orsini A; Pediatric Neurology, University Hospital of Pisa, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Bernasconi DP; Bicocca Bioinformatics Biostatistics and Bioimaging Center, School of Medicine and Surgery, University of Milano-Bicocca, Italy.; Clinical Research and Innovation Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Pietrafusa N; Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy., Ricci E; Health Sciences Department, Università degli Studi di Milano, Milan, Italy.; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy., Manfredini L; Paediatric Chronic Pain and Palliative Care Service, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Balletto G; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy., Bonanni P; Epilepsy Unit, IRCCS E. Medea Scientific Institute, Conegliano, Italy., Canevini MP; Health Sciences Department, Università degli Studi di Milano, Milan, Italy.; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy., De Giorgis V; Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Nobili L; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy., Sartori S; Department of Women's and Child's Health, University of Padua, Padova, Italy.; Paediatric Neurology and Neurophysiology Unit - University Hospital of Padua, Padova, Italy., Savini MN; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy., Viganò I; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy., Specchio N; Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy.; University Hospitals KU Leuven, Leuven, Belgium.
Source: Epilepsia open [Epilepsia Open] 2025 Aug; Vol. 10 (4), pp. 1111-1119. Date of Electronic Publication: 2025 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101692036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9239 (Electronic) Linking ISSN: 24709239 NLM ISO Abbreviation: Epilepsia Open Subsets: MEDLINE
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  Data: Is highly purified cannabidiol a treatment opportunity for drug-resistant epilepsy in subjects with typical Rett syndrome and CDKL5 deficiency disorder?
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  Data: <searchLink fieldCode="AU" term="%22Vignoli+A%22">Vignoli A</searchLink>; Childhood and Adolescence Neuropsychiatry Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy.; Health Sciences Department, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prato+G%22">Prato G</searchLink>; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Alfei+E%22">Alfei E</searchLink>; Pediatric Neurology Unit, Buzzi Children's Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bagnasco+I%22">Bagnasco I</searchLink>; Division of Child Neuropsychiatry, Martini Hospital, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Danieli+A%22">Danieli A</searchLink>; Epilepsy Unit, IRCCS E. Medea Scientific Institute, Conegliano, Italy.<br /><searchLink fieldCode="AU" term="%22Celario+M%22">Celario M</searchLink>; Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Favaro+J%22">Favaro J</searchLink>; Department of Women's and Child's Health, University of Padua, Padova, Italy.; Paediatric Neurology and Neurophysiology Unit - University Hospital of Padua, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Matricardi+S%22">Matricardi S</searchLink>; Department of Pediatrics, University of Chieti, Chieti, Italy.<br /><searchLink fieldCode="AU" term="%22Operto+FF%22">Operto FF</searchLink>; Department of Science of Health School of Medicine, University Magna Greacia of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Orsini+A%22">Orsini A</searchLink>; Pediatric Neurology, University Hospital of Pisa, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Bernasconi+DP%22">Bernasconi DP</searchLink>; Bicocca Bioinformatics Biostatistics and Bioimaging Center, School of Medicine and Surgery, University of Milano-Bicocca, Italy.; Clinical Research and Innovation Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pietrafusa+N%22">Pietrafusa N</searchLink>; Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+E%22">Ricci E</searchLink>; Health Sciences Department, Università degli Studi di Milano, Milan, Italy.; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Manfredini+L%22">Manfredini L</searchLink>; Paediatric Chronic Pain and Palliative Care Service, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Balletto+G%22">Balletto G</searchLink>; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bonanni+P%22">Bonanni P</searchLink>; Epilepsy Unit, IRCCS E. Medea Scientific Institute, Conegliano, Italy.<br /><searchLink fieldCode="AU" term="%22Canevini+MP%22">Canevini MP</searchLink>; Health Sciences Department, Università degli Studi di Milano, Milan, Italy.; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Giorgis+V%22">De Giorgis V</searchLink>; Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Nobili+L%22">Nobili L</searchLink>; Unit of Child Neuropsychiatry, IRCCS Istituto Giannina Gaslini, Full Member of European Reference Network EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Sartori+S%22">Sartori S</searchLink>; Department of Women's and Child's Health, University of Padua, Padova, Italy.; Paediatric Neurology and Neurophysiology Unit - University Hospital of Padua, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Savini+MN%22">Savini MN</searchLink>; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Viganò+I%22">Viganò I</searchLink>; Child Neurology Unit, Epilepsy Center, San Paolo Hospital, Member of European Reference Network EpiCARE, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Specchio+N%22">Specchio N</searchLink>; Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy.; University Hospitals KU Leuven, Leuven, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101692036%22">Epilepsia open</searchLink> [Epilepsia Open] 2025 Aug; Vol. 10 (4), pp. 1111-1119. <i>Date of Electronic Publication: </i>2025 Jun 21.
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