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Novel Kinesin Family Member 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal Transactive Response DNA Binding Protein 43 kDa Interactions and Dendritic Atrophy.

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Title: Novel Kinesin Family Member 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal Transactive Response DNA Binding Protein 43 kDa Interactions and Dendritic Atrophy.
Authors: Homayoun H; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., DeChellis-Marks MR; Department of Neurobiology, LiveLikeLou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania., Kofler J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Fricklas G; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Gleixner AM; Department of Neurobiology, LiveLikeLou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Yeh FC; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Lacomis D; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurobiology, LiveLikeLou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Chu CT; Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: ctc4@pitt.edu., Donnelly CJ; Department of Neurobiology, LiveLikeLou Center for ALS Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: cjdon25@pitt.edu.
Source: The American journal of pathology [Am J Pathol] 2025 Nov; Vol. 195 (11), pp. 2161-2175. Date of Electronic Publication: 2025 Jun 19.
Publication Type: Journal Article; Case Reports
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-2191
DOI:10.1016/j.ajpath.2025.05.018