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Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.

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Title: Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
Authors: He SY; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Bu YR; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Xu J; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Wang YM; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Feng TX; Department of Urology, Xijing Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China., Li PJ; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Zhao YX; Department of Nephrology, Tangdu Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China., Ge YL; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. 15339046217@163.com., Xie MJ; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. xiemanjiang@fmmu.edu.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Oct; Vol. 30 (9-10), pp. 2225-2237. Date of Electronic Publication: 2025 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-675X
DOI:10.1007/s10495-025-02138-5