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Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.

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Title: Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
Authors: He SY; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Bu YR; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Xu J; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Wang YM; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Feng TX; Department of Urology, Xijing Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China., Li PJ; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China., Zhao YX; Department of Nephrology, Tangdu Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China., Ge YL; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. 15339046217@163.com., Xie MJ; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. xiemanjiang@fmmu.edu.cn.
Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2025 Oct; Vol. 30 (9-10), pp. 2225-2237. Date of Electronic Publication: 2025 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acute high-altitude hypoxia induced NLRP3 inflammasome activation in pulmonary artery smooth muscle cells by BMAL1 targeting mitochondrial VDAC1-mediated MtDNA leakage.
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  Data: <searchLink fieldCode="AU" term="%22He+SY%22">He SY</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.<br /><searchLink fieldCode="AU" term="%22Bu+YR%22">Bu YR</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+YM%22">Wang YM</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.<br /><searchLink fieldCode="AU" term="%22Feng+TX%22">Feng TX</searchLink>; Department of Urology, Xijing Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Li+PJ%22">Li PJ</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China.<br /><searchLink fieldCode="AU" term="%22Zhao+YX%22">Zhao YX</searchLink>; Department of Nephrology, Tangdu Hospital of Air Force Medical University, No.127 Changle West Road, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Ge+YL%22">Ge YL</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. 15339046217@163.com.<br /><searchLink fieldCode="AU" term="%22Xie+MJ%22">Xie MJ</searchLink>; Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of Ministry of Education, Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, China. xiemanjiang@fmmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229712129%22">Apoptosis : an international journal on programmed cell death</searchLink> [Apoptosis] 2025 Oct; Vol. 30 (9-10), pp. 2225-2237. <i>Date of Electronic Publication: </i>2025 Jun 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9712129 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-675X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213608185%22">13608185 </searchLink><i>NLM ISO Abbreviation: </i>Apoptosis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10495-025-02138-5
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      – Code: eng
        Text: English
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              Text: 2025 Oct
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              Y: 2025
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