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Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell-Derived Human Hepatocytes In Vitro Using Microfluidics Technology.

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Title: Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell-Derived Human Hepatocytes In Vitro Using Microfluidics Technology.
Authors: Rodrigues JS; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Relvas S; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal., Condelipes PM; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal., Silva B; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal., Bozzo R; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., de Pinho PG; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal., Chu V; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal., Remião F; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal., Conde JP; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal.; Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal., Miranda JP; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Source: Biotechnology journal [Biotechnol J] 2025 Jun; Vol. 20 (6), pp. e70037.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101265833 Publication Model: Print Cited Medium: Internet ISSN: 1860-7314 (Electronic) Linking ISSN: 18606768 NLM ISO Abbreviation: Biotechnol J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rodrigues+JS%22">Rodrigues JS</searchLink>; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Relvas+S%22">Relvas S</searchLink>; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Condelipes+PM%22">Condelipes PM</searchLink>; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Silva+B%22">Silva B</searchLink>; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Bozzo+R%22">Bozzo R</searchLink>; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22de+Pinho+PG%22">de Pinho PG</searchLink>; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Chu+V%22">Chu V</searchLink>; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Remião+F%22">Remião F</searchLink>; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.; UCIBIO, Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Conde+JP%22">Conde JP</searchLink>; Instituto de Engenharia de Sistemas e Computadores - Microsistemas e Nanotecnologias (INESC MN), Lisbon, Portugal.; Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Miranda+JP%22">Miranda JP</searchLink>; Research Institute for Medicines (imed), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
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              Text: 2025 Jun
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