Synthetic host defense peptide inhibits SARS-CoV-2 replication in vitro.

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Title: Synthetic host defense peptide inhibits SARS-CoV-2 replication in vitro.
Authors: Harfoot R; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Lawley B; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Hernández LC; Department of Pediatric Dentistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Kuang J; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand., Hills FR; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Sinha S; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Allais MJM; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Institute of Environmental Science and Research, Wellington, New Zealand., Bird TW; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand., Hird CP; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada., Taylor JA; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Bostina M; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Comoletti D; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand., Haney EF; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada., Hancock REW; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada., Pletzer D; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand., Quiñones-Mateu ME; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Aug 06; Vol. 69 (8), pp. e0170024. Date of Electronic Publication: 2025 Jun 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthetic host defense peptide inhibits SARS-CoV-2 replication in vitro.
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  Data: <searchLink fieldCode="AU" term="%22Harfoot+R%22">Harfoot R</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lawley+B%22">Lawley B</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hernández+LC%22">Hernández LC</searchLink>; Department of Pediatric Dentistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kuang+J%22">Kuang J</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hills+FR%22">Hills FR</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Sinha+S%22">Sinha S</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Allais+MJM%22">Allais MJM</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; Institute of Environmental Science and Research, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bird+TW%22">Bird TW</searchLink>; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Hird+CP%22">Hird CP</searchLink>; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Taylor+JA%22">Taylor JA</searchLink>; School of Biological Sciences, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bostina+M%22">Bostina M</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Comoletti+D%22">Comoletti D</searchLink>; School of Biomedical Sciences, Victoria University of Wellington, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Haney+EF%22">Haney EF</searchLink>; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Hancock+REW%22">Hancock REW</searchLink>; Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Pletzer+D%22">Pletzer D</searchLink>; Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.<br /><searchLink fieldCode="AU" term="%22Quiñones-Mateu+ME%22">Quiñones-Mateu ME</searchLink>; Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
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