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A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants.

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Title: A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants.
Authors: Sambe T; Clinical Research Center for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan; Department of Clinical Pharmacology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan., Miwa T; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan., Yoneyama K; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan., Ishida T; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan., Yamazaki T; Clinical Research Center for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Shima M; Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Japan. Electronic address: mshima@naramed-u.ac.jp.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2025 Oct; Vol. 23 (10), pp. 3098-3110. Date of Electronic Publication: 2025 Jun 17.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants.
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  Data: <searchLink fieldCode="AU" term="%22Sambe+T%22">Sambe T</searchLink>; Clinical Research Center for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan; Department of Clinical Pharmacology, Graduate School of Medicine, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miwa+T%22">Miwa T</searchLink>; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoneyama+K%22">Yoneyama K</searchLink>; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ishida+T%22">Ishida T</searchLink>; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamazaki+T%22">Yamazaki T</searchLink>; Clinical Research Center for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shima+M%22">Shima M</searchLink>; Thrombosis and Hemostasis Research Center, Nara Medical University, Kashihara, Japan. Electronic address: mshima@naramed-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101170508%22">Journal of thrombosis and haemostasis : JTH</searchLink> [J Thromb Haemost] 2025 Oct; Vol. 23 (10), pp. 3098-3110. <i>Date of Electronic Publication: </i>2025 Jun 17.
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  Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170508 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215387836%22">15387836 </searchLink><i>NLM ISO Abbreviation: </i>J Thromb Haemost <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jtha.2025.06.013
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      – Code: eng
        Text: English
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        StartPage: 3098
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      – TitleFull: A first-in-human study of NXT007, a next-generation, activated factor VIII-mimetic bispecific antibody, in healthy participants.
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            NameFull: Sambe T
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            NameFull: Miwa T
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              Text: 2025 Oct
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              Value: 10
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            – TitleFull: Journal of thrombosis and haemostasis : JTH
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