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Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation.

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Title: Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation.
Authors: van den Beukel MD; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands., Zhang L; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands., van der Meulen S; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands., Borggreven NV; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands., Nugteren S; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands., Brouwer MC; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Pouw RB; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Sanquin Diagnostics Services, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious Diseases, Immunology, Amsterdam, the Netherlands., Gelderman KA; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Sanquin Diagnostics Services, Amsterdam, the Netherlands; Erasmus Medical Center, Department of Immunology, Laboratory Medical Immunology, Rotterdam, the Netherlands., de Ru AH; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Janssen GMC; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., van Veelen PA; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands., Knevel R; Leiden University Medical Center, Department of Rheumatology, Leiden, the Netherlands., Parren PWHI; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands; Gyes BV, Utrecht, the Netherlands., Trouw LA; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands. Electronic address: L.A.Trouw@lumc.nl.
Source: Journal of autoimmunity [J Autoimmun] 2025 Jul; Vol. 155, pp. 103444. Date of Electronic Publication: 2025 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 8812164 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9157 (Electronic) Linking ISSN: 08968411 NLM ISO Abbreviation: J Autoimmun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation.
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  Data: <searchLink fieldCode="AU" term="%22van+den+Beukel+MD%22">van den Beukel MD</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Meulen+S%22">van der Meulen S</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Borggreven+NV%22">Borggreven NV</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nugteren+S%22">Nugteren S</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Brouwer+MC%22">Brouwer MC</searchLink>; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pouw+RB%22">Pouw RB</searchLink>; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Sanquin Diagnostics Services, Amsterdam, the Netherlands; Amsterdam Institute for Immunology and Infectious Diseases, Immunology, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderman+KA%22">Gelderman KA</searchLink>; Sanquin Research, and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Sanquin Diagnostics Services, Amsterdam, the Netherlands; Erasmus Medical Center, Department of Immunology, Laboratory Medical Immunology, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Ru+AH%22">de Ru AH</searchLink>; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+GMC%22">Janssen GMC</searchLink>; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Veelen+PA%22">van Veelen PA</searchLink>; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Knevel+R%22">Knevel R</searchLink>; Leiden University Medical Center, Department of Rheumatology, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Parren+PWHI%22">Parren PWHI</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands; Gyes BV, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Trouw+LA%22">Trouw LA</searchLink>; Leiden University Medical Center, Department of Immunology, Leiden, the Netherlands. Electronic address: L.A.Trouw@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%228812164%22">Journal of autoimmunity</searchLink> [J Autoimmun] 2025 Jul; Vol. 155, pp. 103444. <i>Date of Electronic Publication: </i>2025 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8812164 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9157 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208968411%22">08968411 </searchLink><i>NLM ISO Abbreviation: </i>J Autoimmun <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul
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