A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.

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Title: A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.
Authors: Eisenmann ED; The Ohio State University, Columbus, Ohio., Swords R; Oregon Health & Science University, Portland, Oregon., Huang Y; The Ohio State University, Columbus, Ohio., Orwick S; The Ohio State University, Columbus, Ohio., Buelow D; The Ohio State University, Columbus, Ohio., Abbott N; The Ohio State University, Columbus, Ohio., Phelps M; The Ohio State University, Columbus, Ohio., Zeidner J; University of North Carolina, Chapel Hill, North Carolina., Foster MC; University of North Carolina, Chapel Hill, North Carolina., Lin TL; University of Kansas, Kansas City, Kansas., Baer MR; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Madanat YF; University of Texas Southwestern Medical Center, Dallas, Texas., Kovacsovics T; The University of Utah, Salt Lake City, Utah., Redner R; University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Al-Mansour Z; University of Florida, Gainesville, Florida., Bhatnagar B; West Virginia University Cancer Institute, Wheeling, West Virginia., Stefanos M; The Ohio State University, Columbus, Ohio., Martycz M; The Ohio State University, Columbus, Ohio., Druggan F; The Ohio State University, Columbus, Ohio., Chen TL; The Ohio State University, Columbus, Ohio., Yocum AO; The Leukemia & Lymphoma Society, Rye Brook, New York., Borate U; The Ohio State University, Columbus, Ohio., Druker BJ; Oregon Health & Science University, Portland, Oregon., Burd A; The Leukemia & Lymphoma Society, Rye Brook, New York., Levine RL; Memorial Sloan Kettering Cancer Center, New York City, New York., Byrd JC; University of Cincinnati, Cincinnati, Ohio., Baker SD; The Ohio State University, Columbus, Ohio., Mims AS; The Ohio State University, Columbus, Ohio.
Source: Cancer research communications [Cancer Res Commun] 2025 Jul 01; Vol. 5 (7), pp. 1129-1139.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2767-9764
DOI:10.1158/2767-9764.CRC-25-0091