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A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.

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Title: A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.
Authors: Eisenmann ED; The Ohio State University, Columbus, Ohio., Swords R; Oregon Health & Science University, Portland, Oregon., Huang Y; The Ohio State University, Columbus, Ohio., Orwick S; The Ohio State University, Columbus, Ohio., Buelow D; The Ohio State University, Columbus, Ohio., Abbott N; The Ohio State University, Columbus, Ohio., Phelps M; The Ohio State University, Columbus, Ohio., Zeidner J; University of North Carolina, Chapel Hill, North Carolina., Foster MC; University of North Carolina, Chapel Hill, North Carolina., Lin TL; University of Kansas, Kansas City, Kansas., Baer MR; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland., Madanat YF; University of Texas Southwestern Medical Center, Dallas, Texas., Kovacsovics T; The University of Utah, Salt Lake City, Utah., Redner R; University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Al-Mansour Z; University of Florida, Gainesville, Florida., Bhatnagar B; West Virginia University Cancer Institute, Wheeling, West Virginia., Stefanos M; The Ohio State University, Columbus, Ohio., Martycz M; The Ohio State University, Columbus, Ohio., Druggan F; The Ohio State University, Columbus, Ohio., Chen TL; The Ohio State University, Columbus, Ohio., Yocum AO; The Leukemia & Lymphoma Society, Rye Brook, New York., Borate U; The Ohio State University, Columbus, Ohio., Druker BJ; Oregon Health & Science University, Portland, Oregon., Burd A; The Leukemia & Lymphoma Society, Rye Brook, New York., Levine RL; Memorial Sloan Kettering Cancer Center, New York City, New York., Byrd JC; University of Cincinnati, Cincinnati, Ohio., Baker SD; The Ohio State University, Columbus, Ohio., Mims AS; The Ohio State University, Columbus, Ohio.
Source: Cancer research communications [Cancer Res Commun] 2025 Jul 01; Vol. 5 (7), pp. 1129-1139.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Phase 1b/2 Study of TP-0903 and Decitabine Targeting Mutant TP53 and/or Complex Karyotype in Patients with Untreated Acute Myeloid Leukemia ≥Age 60 Years.
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  Data: <searchLink fieldCode="AU" term="%22Eisenmann+ED%22">Eisenmann ED</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Swords+R%22">Swords R</searchLink>; Oregon Health & Science University, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Orwick+S%22">Orwick S</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Buelow+D%22">Buelow D</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Abbott+N%22">Abbott N</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Phelps+M%22">Phelps M</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Zeidner+J%22">Zeidner J</searchLink>; University of North Carolina, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Foster+MC%22">Foster MC</searchLink>; University of North Carolina, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Lin+TL%22">Lin TL</searchLink>; University of Kansas, Kansas City, Kansas.<br /><searchLink fieldCode="AU" term="%22Baer+MR%22">Baer MR</searchLink>; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Madanat+YF%22">Madanat YF</searchLink>; University of Texas Southwestern Medical Center, Dallas, Texas.<br /><searchLink fieldCode="AU" term="%22Kovacsovics+T%22">Kovacsovics T</searchLink>; The University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Redner+R%22">Redner R</searchLink>; University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Al-Mansour+Z%22">Al-Mansour Z</searchLink>; University of Florida, Gainesville, Florida.<br /><searchLink fieldCode="AU" term="%22Bhatnagar+B%22">Bhatnagar B</searchLink>; West Virginia University Cancer Institute, Wheeling, West Virginia.<br /><searchLink fieldCode="AU" term="%22Stefanos+M%22">Stefanos M</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Martycz+M%22">Martycz M</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Druggan+F%22">Druggan F</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Chen+TL%22">Chen TL</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Yocum+AO%22">Yocum AO</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York.<br /><searchLink fieldCode="AU" term="%22Borate+U%22">Borate U</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Druker+BJ%22">Druker BJ</searchLink>; Oregon Health & Science University, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Burd+A%22">Burd A</searchLink>; The Leukemia & Lymphoma Society, Rye Brook, New York.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Memorial Sloan Kettering Cancer Center, New York City, New York.<br /><searchLink fieldCode="AU" term="%22Byrd+JC%22">Byrd JC</searchLink>; University of Cincinnati, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Baker+SD%22">Baker SD</searchLink>; The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Mims+AS%22">Mims AS</searchLink>; The Ohio State University, Columbus, Ohio.
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  Data: <searchLink fieldCode="JN" term="%229918281580506676%22">Cancer research communications</searchLink> [Cancer Res Commun] 2025 Jul 01; Vol. 5 (7), pp. 1129-1139.
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  Data: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918281580506676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2767-9764 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227679764%22">27679764 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res Commun <i>Subsets: </i>MEDLINE
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