Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis.
Saved in:
| Title: | Elevated Sphingosine Levels Suppress Profibrotic TGF-β Signaling via the PKC/miR-21/SMAD7 Axis in Sphingosine Kinase 2-Deficient Renal Fibroblasts and Unilateral Ureteral Obstruction-Induced Kidney Fibrosis. |
|---|---|
| Authors: | Oftring A; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Wagner V; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany., Thomas D; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany.; University Hospital, pharmazentrum, Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany., Huber LS; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Geisslinger G; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, Frankfurt am Main, Germany.; University Hospital, pharmazentrum, Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany., Schaefer L; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Vutukuri R; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Pfeilschifter J; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany., Schwalm S; University Hospital, pharmazentrum, Institute of General Pharmacology and Toxicology, Goethe University, Frankfurt am Main, Germany. |
| Source: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Jun 30; Vol. 39 (12), pp. e70768. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1530-6860 |
|---|---|
| DOI: | 10.1096/fj.202500506R |
