Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma.

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Title: Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma.
Authors: Traweek RS; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Zoghbi M; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Lazcano R; Department of Pathology, Massachusetts General Hospital, Boston, USA., Cope BM; Department of Surgery, Keesler Medical Center, Biloxi, USA., Bishop AJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Farooqi A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Mitra D; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Yoder AK; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Guadagnolo BA; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ingram DR; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Wani K; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Shamsutdinova D; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA., Wang WL; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Scally CP; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Keung EZ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Torres KE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Hunt KK; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ratan R; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Livingston JA; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Nakazawa MS; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Araujo DM; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Patel S; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ravi V; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Conley AP; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Zarzour MA; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Somaiah N; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Roland CL; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Nassif Haddad EF; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: efnassif@mdanderson.org.
Source: ESMO open [ESMO Open] 2025 Jul; Vol. 10 (7), pp. 105493. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2059-7029
DOI:10.1016/j.esmoop.2025.105493