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Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma.

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Title: Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma.
Authors: Traweek RS; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Zoghbi M; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Lazcano R; Department of Pathology, Massachusetts General Hospital, Boston, USA., Cope BM; Department of Surgery, Keesler Medical Center, Biloxi, USA., Bishop AJ; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Farooqi A; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Mitra D; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Yoder AK; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Guadagnolo BA; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ingram DR; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Wani K; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Shamsutdinova D; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA., Wang WL; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Scally CP; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Keung EZ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Torres KE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Hunt KK; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ratan R; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Livingston JA; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Nakazawa MS; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Araujo DM; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Patel S; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Ravi V; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Conley AP; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Zarzour MA; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Somaiah N; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Roland CL; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA., Nassif Haddad EF; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: efnassif@mdanderson.org.
Source: ESMO open [ESMO Open] 2025 Jul; Vol. 10 (7), pp. 105493. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hyalinization-based pathologic response and immune infiltration following neoadjuvant radiotherapy with or without immune-checkpoint blockade in localized undifferentiated pleomorphic sarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Traweek+RS%22">Traweek RS</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Zoghbi+M%22">Zoghbi M</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Lazcano+R%22">Lazcano R</searchLink>; Department of Pathology, Massachusetts General Hospital, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Cope+BM%22">Cope BM</searchLink>; Department of Surgery, Keesler Medical Center, Biloxi, USA.<br /><searchLink fieldCode="AU" term="%22Bishop+AJ%22">Bishop AJ</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Farooqi+A%22">Farooqi A</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Mitra+D%22">Mitra D</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Yoder+AK%22">Yoder AK</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Guadagnolo+BA%22">Guadagnolo BA</searchLink>; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Ingram+DR%22">Ingram DR</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Wani+K%22">Wani K</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Shamsutdinova+D%22">Shamsutdinova D</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Lazar+AJ%22">Lazar AJ</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Wang+WL%22">Wang WL</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Scally+CP%22">Scally CP</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Keung+EZ%22">Keung EZ</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Torres+KE%22">Torres KE</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Hunt+KK%22">Hunt KK</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Ratan+R%22">Ratan R</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Livingston+JA%22">Livingston JA</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Nakazawa+MS%22">Nakazawa MS</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Araujo+DM%22">Araujo DM</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Patel+S%22">Patel S</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Ravi+V%22">Ravi V</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Conley+AP%22">Conley AP</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Zarzour+MA%22">Zarzour MA</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Somaiah+N%22">Somaiah N</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Roland+CL%22">Roland CL</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Nassif+Haddad+EF%22">Nassif Haddad EF</searchLink>; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: efnassif@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2025 Jul; Vol. 10 (7), pp. 105493. <i>Date of Electronic Publication: </i>2025 Jun 24.
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