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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.

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Title: ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.
Authors: de Faria FW; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Riedel NC; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Münter D; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Interlandi M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Göbel C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Altendorf L; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Richter M; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Melcher V; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Thomas C; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Roy R; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Schoof M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Bedzhov I; Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Moreno N; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Graf M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Hotfilder M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Holdhof D; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.; West German Cancer Center (WTZ), Network Partner Site, University Hospital Münster, Münster, Germany., Bruns AK; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Brentrup A; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Liesche-Starnecker F; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany., Maerkl B; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany., Sandmann S; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Varghese J; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Dugas M; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.; Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany., Pinto PH; Department of Pathology, Children's Hospital of Brasilia Jose de Alencar, Brasilia, Brazil., Balbach ST; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Lu IN; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Soehnlein O; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Canak A; Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Ebinger M; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Schuhmann M; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Schittenhelm J; Department of Neuropathology, University Medical Hospital, Eberhard Karls University Tübingen, Tübingen, Germany., Frühwald MF; Swabian Children's Cancer Center, Pediatric and Adolescent Medicine, University Center Augsburg, Augsburg, Germany., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Albert TK; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Walter C; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Bruder JM; Department for Cell and Developmental Biology, Max Planck Institute for molecular Biomedicine, Münster, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany. kornelius.kerl@ukmuenster.de.
Source: Nature communications [Nat Commun] 2025 Jun 25; Vol. 16 (1), pp. 5394. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-60442-9