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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.

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Title: ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.
Authors: de Faria FW; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Riedel NC; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Münter D; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Interlandi M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Göbel C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Altendorf L; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Richter M; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Melcher V; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Thomas C; Institute of Neuropathology, University Hospital Münster, Münster, Germany., Roy R; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Schoof M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Bedzhov I; Embryonic Self-Organization Research Group, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Moreno N; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Graf M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Hotfilder M; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Holdhof D; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.; West German Cancer Center (WTZ), Network Partner Site, University Hospital Münster, Münster, Germany., Bruns AK; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Brentrup A; Department of Neurosurgery, University Hospital Münster, Münster, Germany., Liesche-Starnecker F; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany., Maerkl B; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany., Sandmann S; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Varghese J; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Dugas M; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.; Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany., Pinto PH; Department of Pathology, Children's Hospital of Brasilia Jose de Alencar, Brasilia, Brazil., Balbach ST; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Lu IN; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Soehnlein O; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Canak A; Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Ebinger M; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Schuhmann M; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany., Schittenhelm J; Department of Neuropathology, University Medical Hospital, Eberhard Karls University Tübingen, Tübingen, Germany., Frühwald MF; Swabian Children's Cancer Center, Pediatric and Adolescent Medicine, University Center Augsburg, Augsburg, Germany., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Albert TK; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany., Walter C; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany., Bruder JM; Department for Cell and Developmental Biology, Max Planck Institute for molecular Biomedicine, Münster, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany. kornelius.kerl@ukmuenster.de.
Source: Nature communications [Nat Commun] 2025 Jun 25; Vol. 16 (1), pp. 5394. Date of Electronic Publication: 2025 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.
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  Data: <searchLink fieldCode="AU" term="%22de+Faria+FW%22">de Faria FW</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Riedel+NC%22">Riedel NC</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Münter+D%22">Münter D</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Interlandi+M%22">Interlandi M</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Göbel+C%22">Göbel C</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Altendorf+L%22">Altendorf L</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Melcher+V%22">Melcher V</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas+C%22">Thomas C</searchLink>; Institute of Neuropathology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Roy+R%22">Roy R</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Schoof+M%22">Schoof M</searchLink>; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; 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Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.; West German Cancer Center (WTZ), Network Partner Site, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Bruns+AK%22">Bruns AK</searchLink>; Department of Neurosurgery, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Brentrup+A%22">Brentrup A</searchLink>; Department of Neurosurgery, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Liesche-Starnecker+F%22">Liesche-Starnecker F</searchLink>; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Maerkl+B%22">Maerkl B</searchLink>; Department of Neuropathology, Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sandmann+S%22">Sandmann S</searchLink>; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Varghese+J%22">Varghese J</searchLink>; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Dugas+M%22">Dugas M</searchLink>; Institute of Medical Informatics, Westphalian Wilhelms University Münster, Münster, Germany.; Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pinto+PH%22">Pinto PH</searchLink>; Department of Pathology, Children's Hospital of Brasilia Jose de Alencar, Brasilia, Brazil.<br /><searchLink fieldCode="AU" term="%22Balbach+ST%22">Balbach ST</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Lu+IN%22">Lu IN</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Rossig+C%22">Rossig C</searchLink>; Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Soehnlein+O%22">Soehnlein O</searchLink>; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Canak+A%22">Canak A</searchLink>; Department of Hematology and Oncology, Children's University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ebinger+M%22">Ebinger M</searchLink>; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schuhmann+M%22">Schuhmann M</searchLink>; Department of Neurosurgery, section of Pediatric Neurosurgery, University Hospital Tübingen, and German Cancer Consortium (DKTK) Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schittenhelm+J%22">Schittenhelm J</searchLink>; Department of Neuropathology, University Medical Hospital, Eberhard Karls University Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Frühwald+MF%22">Frühwald MF</searchLink>; 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Department of Pediatric Hematology and Oncology, University Hospital Münster, Münster, Germany. kornelius.kerl@ukmuenster.de.
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